Early initiation of biologics and disease outcomes in adults and children with inflammatory bowel diseases: Results from the epidemiology group of the nationwide israeli inflammatory bowel disease research nucleus cohort
Biologic use in inflammatory bowel disease has been steadily increasing, with arguments that early initiation or a "top down" approach will positively impact natural history of disease. The true effect of timing to initiation of biologics is still contentious. This study examined rates of steroid dependency and IBD related surgery for those on biologics <3 months, 3-12 1-2 years and 2-3 from diagnosis in 9,477 patients. read more

Review by Prof. Jonathan O'Donnell (Australia)

Oral vonoprazan appears equivalent to IV PPI for prevention of peptic ulcer rebleeding
Intravenous proton pump inhibitors (IV PPI) have become a standard of care in patients with peptic ulcer hemorrhage whose ulcers are at high risk of re-bleeding. IV PPI decreases rebleeding, re-intervention and mortality. Vonoprazan, a potassium-competitive acid blocker, is a more potent acid blocker than oral PPIs. read more

Review by Prof. Mark Topazian (USA)



P-CAB versus PPI in the eradication of Helicobacter pylori: A systematic review and network meta-analysis
Therapeutic Advances in Gastroenterology
This study aims to compare the effectiveness and safety of potassium-competitive acid blockers (P-CABs) and proton pump inhibitors in eradicating Helicobacter pylori and compare the eradication rate and adverse reactions of vonoprazan-based and tegoprazan-based regimens to explore the efficacy and safety of different Hp eradication strategies.  read more

A comprehensive evaluation of serum circCSPP1 as a novel diagnostic and prognostic biomarker for gastric cancer
Clinics and Research in Hepatology and Gastroenterology via ScienceDirect
Gastric cancer has high incidence and mortality due to its low early screening efficiency. Circular RNAs (CircRNAs) are a new class of non-coding RNAs, which is closely related to GC. Nevertheless, the clinical application value of circRNAs in GC are largely unknown. Therefore, we studied the role of a novel circRNA named circCSPP1 in patients with GC. read more

Complex decision-making for gastroesophageal reflux in children with neurologic impairment
Hospital Pediatrics
GERD impacts children with neurologic impairment, but distinguishing it from other conditions is tough. The 2017 guidelines suggest proton pump inhibitors, diet changes and diagnostic testing. For severe GERD, gastrojejunal tube feeding or surgery may be considered. Canadian doctors' practices were surveyed regarding GERD management. read more

Bariatric surgery tied to higher short-term risk for venous thromboembolism
HealthDay via Medical Xpress
Recent research indicates that while bariatric surgery raises the risk of venous thromboembolism shortly after the procedure, it significantly reduces the risk over the long term. This dual effect highlights the complex balance between immediate risks and lasting benefits. read more

Benefit and harm of aspirin on mortality from gastrointestinal cancers versus bleeding in helicobacter pylori-eradicated patients
Clinical Gastroenterology and Hepatology via ScienceDirect
The researchers investigated the benefit-risk profile of aspirin on mortality reduction from chemoprevention of gastrointestinal cancer versus excess mortality from bleeding among Helicobacter pylori (HP)-eradicated patients, and its interaction with proton pump inhibitors. read more



EASL Congress 2024
When: June 5, 2024 - June 8, 2024
Location: Milan, Italy
Organizer(s): EASL
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83rd Congress of the Spanish Society of Digestive Pathology
When: June 13, 2024 - June 15, 2024
Location: Valencia, Spain
Organizer(s): ISociedad Española de Patología Digestiva
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