ISSUE HIGHLIGHTS

WHAT'S HOT IN THE LITERATURE

Resmetirom in MASH/NASH with Liver Fibrosis
The New England Journal of Medicine
Non-alcoholic steatohepatitis (NASH), recently renamed as metabolic dysfunction–associated steatohepatitis (MASH), is a rapidly growing disease worldwide and is a major reason for liver transplantation. Despite its increasing burden, there is no approved pharmacologic treatment for MASH with liver fibrosis. Recently, in a phase 3 randomized controlled trial, resmetirom, a liver-directed, thyroid hormone receptor beta (THR-β)–selective agonist, has been used to treat patients with MASH and liver fibrosis. read more

Review by Prof. Ahad Eshraghian (Iran)

Risankizumab versus Ustekinumab for Crohn's Disease: When less is more
The New England Journal of Medicine
While a number of advanced therapies are becoming available for the management of inflammatory bowel disease, the appropriate positioning of these therapies in a treatment algorithm is difficult because of limited head-to-head trials. Ustekinumab, a humanized IgG1 monoclonal antibody targets IL12 and IL23 by blocking the p40 subunit shared by both of these cytokines while risankizumab is a p19 blocking antibody that blocks the action of IL23 only. read more

Review by Prof. Vishal Sharma (India)

GI NEWS AROUND THE WORLD

Shifting targets for eosinophilic oesophagitis

Nature Reviews
Two phase III trials of new drugs for eosinophilic oesophagitis have been reported in The New England Journal of Medicine. The findings not only highlight new treatments for the condition, but also potentially shift the emphasis for future therapeutic targets and diagnostic criteria. read more

Intestinal ultrasound may predict Stelara response at 1 year in Crohn's disease

Healio
Multimodal intestinal ultrasound performed at 24 weeks can provide "useful information" for predicting endoscopic response at one year in patients with active Crohn's disease initiating treatment with Stelara, according to researchers. read more

Mutational and transcriptional profile predicts the prognosis of stage IV gastric cancer

Arab Journal of Gastroenterology via ScienceDirect
The clinicopathological risk factors in the prognosis of stage IV gastric cancer have been comprehensively studied. However, the influencing factors of stage IV gastric cancer prognosis at genomic and transcriptional levels have not been well defined. read more

Hepatitis E virus: From innate sensing to adaptive immune responses

Nature Reviews
Hepatitis E virus infections are a major cause of acute viral hepatitis worldwide. In immunocompetent individuals, most remain asymptomatic, but can cause up to 30% mortality in pregnant women, become chronic in immunocompromised patients, and cause extrahepatic manifestations. The host immune response to different HEV genotypes is critical for infection outcomes. Current vaccines and future research are discussed. read more

Dupixent induces histologic remission in up to 68% of children with PPI-refractory EoE

Healio
Treatment with Dupixent led to histologic remission at week 16 among a greater percentage of pediatric patients with eosinophilic esophagitis refractory to proton-pump inhibitor therapy compared with placebo, according to study results. read more

Leukocyte telomere length in subjects with metabolic dysfunction-associated steatotic liver disease

Arab Journal of Gastroenterology via ScienceDirect
This study aimed to examine the association between peripheral leukocyte telomere length and indicators of metabolic abnormalities in subjects with metabolic dysfunction-associated steatotic liver disease (MASLD) assessed by magnetic resonance imaging. read more

WGO NEWS

EVENTS CALENDAR

2nd International Conference of Nepalese Society of Gastroenterologists
When: August 23, 2024 - August 24, 2024
Location: Kathmandu - Nepal
Organizer(s): Nepalese Society of Gastroenterologists
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XII Congreso Nacional de Gastroenterologìa y Endoscopìa Digestiva
When: September 5, 2024 - September 7, 2024
Location: Ciudad de Panama - Panama
Organizer(s): Asociacion Panameña de Gastroenterologìa y Endoscopia Digestiva
Learn More