ISSUE HIGHLIGHTS

WHAT'S HOT IN THE LITERATURE

Supplementing taurine may play an important role in anti-cancer therapy
Cell
This study reveals the crucial role of SLC6A6 in cancer progression, particularly how it regulates the tumor immune environment and CD8+T cell function by affecting the availability of taurine. The discovery of SLC6A6 not only provides a new target for cancer treatment but also offers a new strategy for improving the efficacy of current immunotherapy, namely activating exhausted T cells through taurine supplementation read more

Review by Prof. Zikai Wang (China)

Extended mesenteric resection in Crohn's disease: Not spicy enough
The Lancet Gastroenterology & Hepatology
Recent studies including the LIRIC trial as well as data from the Danish national cohort have increased interest in surgical management of Crohn’s disease. Upfront surgery is a reasonable option for many patients with Crohn’s disease including those with stricturing or limited ileocecal disease but comes with the risk of postoperative recurrence. Postoperative recurrence typically occurs at the neo-terminal ileum and the endoscopic recurrence precedes and serves as a proxy indicator for clinical or surgical recurrence. read more

Review by Prof. Vishal Sharma (India)

GI NEWS AROUND THE WORLD

Endoscopic interventions in pancreatic strictures and stones: A structured approach

Indian Journal of Gastroenterology via Springer Link
Chronic pancreatitis is an irreversible disease causing pain due to ductal hypertension. Advances in technology include endoscopic retrograde cholangiography, stenting, and extracorporeal shockwave lithotripsy for small and large pancreatic calculi. read more

Mapping neuroimmune interactions in the gut

Nature
New research has mapped neuroimmune interactions in the mouse gut, revealing that TRPV1-expressing nociceptor neurons (involved in visceral pain) control and suppress regulatory T (Treg) cells in the gut, increasing susceptibility to colitis in mouse models. The findings potentially link pain signalling with immunomodulatory mechanisms in the gut. read more

Impact of fecal microbiota transplantation in severe alcoholic hepatitis: A systematic review and meta-analysis

PubMed
Severe alcoholic hepatitis (SAH) is a serious condition with few treatments. By modifying the gut-liver axis, fecal microbiota transplantation (FMT) was proposed as a treatment for SAH. The purpose of this meta-analysis was to evaluate the efficacy of FMT versus the standard of care (SOC) in improving SAH patient survival rates. read more

Vitamin E shows potential in addressing liver inflammation in MASLD patients

Wiley Online
Despite research on vitamin E's benefits for metabolic dysfunction-associated steatotic liver disease (MASLD), its use remains limited. This study evaluates vitamin E's impact on liver inflammation markers and histological improvements in MASLD, focusing on serum ALT, AST, and MASH resolution. Read More read more

WGO NEWS

EVENTS CALENDAR

IFSO World Congress 2024
When: September 3, 2024 - September 6, 2024
Location: Melbourne, Australia
Organizer(s): International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO)
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XII Congreso Nacional de Gastroenterologìa y Endoscopìa Digestiva
When: September 5, 2024 - September 7, 2024
Location: Ciudad de Panama - Panama
Organizer(s): Asociacion Panameña de Gastroenterologìa y Endoscopia Digestiva
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ALEH Congress 2024/
When: September 9, 2024 - September 11, 2024
Location: Santiago, Chile
Organizer(s): Asociación Latinoamericana para el Estudio del Hígado (ALEH)
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