ISSUE HIGHLIGHTS

WHAT'S HOT IN THE LITERATURE

Tryptophan metabolites produced by the gut microbiome protect against enteric pathogens
Nature
One function of the gut microbiome is providing colonization resistance to protect the host against enteric pathogens, but this phenomenon remains poorly understood. This study delineates a noncanonical colonization resistance pathway against attaching and effacing (AE) pathogens. In this study, bacterial tryptophan metabolites like IEt, IPyA, and I3A can protect mice against Citrobacter rodentium infection, by activation of the host neurotransmitter dopamine receptor D2 (DRD2) within the intestinal epithelium. read more

Review by Prof. Zikai Wang (China)

For hepatitis C access is the key to success
Hepatology
One of the great success stories in medicine over the span of my career has been hepatitis C. Cases of hepatitis which did not fit with either A or B began to emerge in the 1970s and 80s and were given a name that highlighted our ignorance — non-A non-B hepatitis. Various theories for its causation were promoted only to be discarded with the definitive description of the hepatitis C virus and, not too soon later, the formulation of anti-viral regimens which very quickly have proven curative. read more

Review by Prof. Eamonn Quigley (USA)

GI NEWS AROUND THE WORLD

Surgery for Crohn's disease is associated with a dysbiotic microbiome and metabolome
Cellular and Molecular Gastroenterology and Hepatology via ScienceDirect
Crohn's disease is associated with alterations in the gut microbiome and metabolome described as dysbiosis. We characterized the microbial and metabolic consequences of ileal resection, the most common Crohn's disease surgery. read more

The future of endoscopy training with virtual reality
Baishideng Publishing Group Inc
The COVID-19 pandemic has challenged and reshaped medical training, unveiling the shortcomings of traditional methods. Virtual reality, with its immersive and interactive 3D environments, offers a novel approach. This technology not only mimics real-world scenarios but also addresses urgent training needs, enhancing skill acquisition and reducing risks. read more

Fibrosis evaluation in chronic hepatitis B: FIB-6 score
The Saudi Journal of Gastroenterology via LWW Journals
Chronic Hepatitis B virus significantly impacts global health, affecting 300 million people and causing around 820,000 deaths annually. Evaluating liver disease severity, which involves checking fibrosis and HBV replication, is vital for treatment and monitoring future complications, like liver cancer. Noninvasive tests are preferred for assessing liver fibrosis, offering widespread accessibility and cost-effectiveness. read more

Efficacy and safety of potassium-competitive acid inhibitors in the treatment of gastroesophageal reflux
Taylor & Francis Online
Gastroesophageal reflux disease is a common disease caused by reflux of gastric contents to the esophagus. Proton-pump inhibitors are recommended as a first-line therapy to treat GERD. Recently, the potassium-competitive acid inhibitors have been increasingly in use in clinical practice. We aimed to evaluate the efficacy and safety of P-CABs in GERD. read more

Proportion of inflammatory bowel diseases patients with suboptimal disease control in daily clinical practice
United European Gastroenterology Journal via Wiley Online Library
Inflammatory bowel diseases, like Crohn's disease and ulcerative colitis, progress and inflict significant patient burdens due to ineffective treatments and management. The IBD-PODCAST study focuses on quantifying patients experiencing suboptimal disease control in real-world scenarios read more

WGO NEWS

EVENTS CALENDAR

DDW 2024
When: May 18-21, 2024
Location: Washington, DC, United States
Organizer(s): AASLD, AGA, ASGE and SSAT
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EASL Congress 2024
When: June 5, 2024 - June 8, 2024
Location: Milan, Italy
Organizer(s): EASL
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83rd Congress of the Spanish Society of Digestive Pathology
When: June 13, 2024 - June 15, 2024
Location: Valencia, Spain
Organizer(s): ISociedad Española de Patología Digestiva
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