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Risk of gastrointestinal bleeding in patients with end-stage renal disease: The link between gut, heart and kidneys
Gastroenterology Research and Practice
Patients with end-stage renal disease have a five times higher risk of gastrointestinal bleed and mortality than the general population. Aortic stenosis has been associated with GIB from intestinal angiodysplasia. This retrospective analysis obtained data from the 2012 and 2019 National Inpatient Sample. Read More

Potential biomarker found for inherited liver disease
Gastroenterology & Endoscopy News
Similar improvements in both clinical outcomes and growth were demonstrated in children with inflammatory bowel disease initiated on an intravenous tumor necrosis factor inhibitor originator compared with a biosimilar, according to data presented at Digestive Disease Week 2023. This was the first study to analyze the growth outcomes in this patient population. Read More

Anti-TNF biosimilar demonstrates comparable growth, clinical outcomes in children with IBD
Contemporary Pediatrics
In pancreatic cancer, the role of the endoscopist continues to evolve as technologies like endoscopic ultrasound guided biopsies present clinicians with increasingly accurate information to characterize the tumor microenvironments of individual patients and determine effective targeted therapies, according to Tamas A. Gonda, M.D., who spoke about personalized treatment in early pancreatic cancer. Read More

New agent shows promise in decompensated cirrhosis
Gastroenterology & Endoscopy News
The novel agent GB1211, an oral galectin-3 inhibitor, led to meaningful reductions in liver enzymes among patients with Child-Pugh class B decompensated cirrhosis during the GULLIVER-2 trial. In the phase 2, randomized, double-blind, placebo-controlled study, patients were randomly assigned to receive either 100 mg of GB1211 (Galecto) or placebo twice daily for 12 weeks. Read More

Molecular testing-guided therapy versus susceptibility testing-guided therapy in first-line and third-line Helicobacter pylori eradication
The Lancet: Gastroenterology & Hepatology
Helicobacter pylori infection is an important causal factor of gastric cancer and peptic ulcer disease and is associated with immune thrombocytopenic purpura and functional dyspepsia. In H pylori strains, point mutations in the 23S rRNA and gyrA genes are associated with clarithromycin resistance and levofloxacin resistance, respectively. Read More

How private GI practice could change in 10 years
Becker's GI & Endoscopy
Optical colonoscopy is the gold standard method for the diagnosis of colorectal cancer (CRC) and it allows for biopsy and resection, as well as documentation of synchronous lesions. CT colonography (CTC) and colon endoscopic capsule (CEC) are also recommended as alternative minimally invasive or non-invasive procedures. Prospective studies comparing these three approaches are scarce in the current literature. In light of this, the aim of this pilot study was to compare the efficacy of polyp detection between these three methods in patients with a history of curative surgical resection of CRC. Read More

A head-to-head comparison of computed tomography colonography, optical colonoscopy, and colon endoscopic capsule for the detection of polyps after partial colectomy or rectosigmoidectomy for colorectal cancer
Cureus
Padagis received FDA approval of its abbreviated new drug application for budesonide 2mg rectal foam for the induction of remission in patients with mild to moderate ulcerative colitis, according to a manufacturer release. Read More

EVENTS CALENDAR

BSG Live 2023
When: June 19-22, 2023
Location: Liverpool, United Kingdom
Organizer(s):British Society of Gastroenterology
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2023 International Liver Congress
When: June 21-25, 2023
Location: Vienna, Austria
Organizer(s): EASL
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GUT 2023
When: August 18-20, 2023
Location: Kuala Lumpur, Malaysia
Organizer(s): Malaysian Society of Gastroenterology & Hepatology
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