ISSUE HIGHLIGHTS

WHAT'S HOT IN THE LITERATURE

Which stents are better for endoscopic management of pancreatic necrosis: Metal or plastic?
JEndoscopy
Endoscopic drainage of plastic stents is tedious, time-consuming and technically challenging, with multiple opportunities for missteps and therefore previously limited to few centers. The advent of LAMS about a decade ago was revolutionary, allowing for cystenterostomy using one all-encompassing device platform that obviated the need for tract dilation, wire exchange, and multiple stent placement, reducing the learning curve for adoption. read more

Review by Prof. Kavel Visrodia (USA)

Seladelpar in primary biliary cholangitis
The New England Journal of Medicine
The study demonstrated that seladelpar (a peroxisome proliferator–activated receptor delta agonist) was effective in treatment of patients with PBC who were unresponsive to UDCA therapy. Of note, no major adverse events was reported and in contrast to obeticholic acid, pruritus was significantly decreased with seladelpar in patients with moderate-to-severe pruritus at baseline. read more

Review by Prof. Ahad Eshraghian (Iran)

GI NEWS AROUND THE WORLD

Metabolomic insights in ulcerative colitis: Key signatures and pathways
Therapeutic Advances in Gastroenterology via Sage Journals
Therapeutic Advances in Gastroenterology via Sage Journals Read More

Risk factors for intraoperative, delayed perforation related with gastric endoscopic submucosal dissection
Journal of Gastroenterology and Hepatology via Wiley Online Library
Perforation is a significant complications in endoscopic submucosal dissection for early gastric cancer. Previous studies have focused on risk factors, but most were retrospective with small patient numbers. This multicenter prospective cohort study aims to clarify these factors and assist endoscopists in reducing perforation. Read More

Ultrasound muscle assessment for sarcopenia detection in inflammatory bowel disease: A prospective study
United Eruopean Gastro Journal via Wiley Online
IBD patients often experience sarcopenia, a condition that affects surgical and therapeutic outcomes. Muscle ultrasound is a reliable diagnostic tool for assessing sarcopenia in IBD patients. This research has significant implications for disease management and calls for further validation in larger cohorts. Read More

Serum amyloid A3 amplifies inflammation via bacterial amyloid curli in the gut's nervous system
Cellular and Molecular Gastroenterology and Hepatology via ScienceDirect
Bhayana et al.'s study challenges the belief that corticosteroids cause osteonecrosis in inflammatory bowel disease patients, revealing other factors like smoking, chronic alcohol use, and coexisting disorders like vasculitis, highlighting IBD's inherent risk for AVN, independent of corticosteroid treatment, and highlighting the need for a broader diagnostic lens. Read More

Unlocking the mystery of osteonecrosis in IBD: Beyond steroids
European Journal of Gastroenterology & Hempatology
Bhayana et al.'s study challenges the belief that corticosteroids cause osteonecrosis in inflammatory bowel disease patients, revealing other factors like smoking, chronic alcohol use, and coexisting disorders like vasculitis, highlighting IBD's inherent risk for AVN, independent of corticosteroid treatment, and highlighting the need for a broader diagnostic lens. Read More

WGO NEWS

EVENTS CALENDAR

Scrubs and Heels Leadership Conference 2024
When: April 12-14, 2024
Location: Miami, Florida
Organizer(s): Scrubs and Heels
Learn More